From: KNOTTJ@pc007.nafb.trw.com (Janis Knott) Date: Mon, 8 Aug 1994 07:52:56 PST Subj: ADDERALL (Long) Hi, For all who are interested in ADDERALL, I'll try to give you all the info I received. =========================================================================== Contents: 2.5 mg Dextroamphetamine Saccharate 2.5 mg Amphetamine Asparate 2.5 mg Dextroamphetamine Sulfate 2.5 mg Amphetamine Sulfate ADDERALL/RITALIN COMPARISON * ADDERALL has a more convenient dosing schedule - ADDERALL - 1-2 times a day - Ritalin - 2-3 times a day * ADDERALL's convenient dosing schedule may eliminate in-school administration of the product. * ADDERALL's half life is 7-8 hours compared to 1-3 hours for Ritalin * ADDERALL is indicated for younger children - ADDERALL - 3 years and up - Ritalin - 6 years and up * ADDERALL tablets are scored for more flexible dosing * ADDERALL tablets contain no harmful tartrazine dyes * ADDERALLs name has a low profile with potential abusers * ADDERALL is more cost effective than Ritalin ADDERALL ADVANTAGE COMPARED TO CYLERT * ADDERALL patients do not need liver function tests as does Cylert * ADDERALL has not been associated with hepatic toxicity, Cylert has a black box warning in the Package Insert regarding hepatic toxicity. * ADDERALL does not accumulate in the plasma therefore it can be discontinued on weekends if desired. Cylert on the otherhand accumulates in the plasma and cannot be discontinued on weekends. * ADDERALL has a rapid onset of action thereas Cylert may take 3-4 weeks to see a clinical improvement. * ADDERALL is more cost effective than Cylert. Side Effect % of Patients experiencing Side Effect ADDERALL Methylphenidate (Ritalin) Loss of Appetite 16% 19% Insomnia 8% 27% Headache 0% 1% The Rep from Richwood's name is: Elias Ammar (1-800-536-7878) P.O.B. 6497 Florence, KY 41022 606 282-2100 VOC 606 282-2103 FAX Manufacturer Is: Rexas Pharacal, Valley Stream NY * Comes in 10 & 20 mg * ADDERALL's safety profile has been confirmed over years of clinical use with few reports of adverse reactions and no reported toxicity. * Indications: In Attention Deficit Disorder with Hyperactivity: Amphetamine is indicated as an integral part of a total treatment program which typically includes other remedial measures (psyceducational, social) for a stabilizing effect in children with behavioral syndrome characterized by the following group of developmentally inappropriate symptoms: moderate to severe distractibility, short attention span, hyperactivity, emotional lability and impulsivity. The diagnosis of this syndrome should not be made with finality when these symptoms are only of comparatively recent origin. Nonlocalizing (soft) neurological signs, learning disability and abnormal EEG may or may not be present, and a diagnosis of central nervous system dysfunction may or may not be warranted. * Warnings: When tolerance to the "anorectic" effect develops the recommended dose should not be exceeded in an attempt to increase the effect; rather, the drug should be discontinued. Clinical experience suggest that in psychotic children, administration of Amphetamine may exacerbate symptoms of behavior disturbance and thought disorder. * Not recommended for children under 3 years of age, in children from 3 to 5 years of age, start with 2.5 mg daily, daily dosage may be raised in increments of 2.5 mg at weekly intervals until optimal response is obtained. In children 6 years of age and older, start with 5 mg one or twice daily; daily dosage may be raised in increments of 5 mg at weekly intervals until optimal response is obtained. Only in rare cases will it be necessary to exceed a total of 40 mg per day. Give first dose on awakening; additional doses (1 or 2) at intervals of 4 to 6 hours. I hope this helps. Janis The "Real" Calvin's Mom