CMT Epidemiology
Last updated: 9/16/1995
Epidemiology
Definition from Blackiston's Pocket Medical Dictionary: "epidemiology noun - 1) The study of the occurance and distribution of a disease, usually restricted to epidemic and endemic, but sometimes broadened to include all types of disease. 2) The sum of all factors controlling the presence or absence of a disease. i>epidemiologic adjective"
There are articles published about some aspect of CMT in Russia, Japan, South America, India and other countries. The following are some of the articles related to epidemiology.
- Mostacciuolo ML. Schiavon F. Angelini C. Miccoli B. Piccolo F. Danieli GA., "Frequency of duplication at 17p11.2 in families of northeast Italy with Charcot-Marie-Tooth disease type 1", Neuroepidemiology. 14(2):49-53, 1995.
Northeastern Italy: 9.4/100,000 per 100,000 for CMT-1 of which 82% were CMT-1A (probability in sporadic cases (p = 0.801)
- Mostacciuolo ML. Micaglio G. Fardin P. Danieli GA., "Genetic epidemiology of hereditary motor sensory neuropathies (type I)", American Journal of Medical Genetics. 39(4):479-81, 1991 Jun 15.
Northeastern Italy: 9.37/100,000, Sporatic cases estimated between 3 and 6 X 10(-6).
- MacMillan JC. Harper PS., "The Charcot-Marie-Tooth syndrome: clinical aspects from a population study in South Wales, UK", Clinical Genetics. 45(3):128-34, 1994 Mar.
South Wales: 16.7 per 100,000 for CMT of the South Wales adult population
- Holmberg BH., "Charcot-Marie-Tooth disease in northern Sweden: an epidemiological and clinical study", Acta Neurologica Scandinavica. 87(5):416-22, 1993 May.
Northern Sweden: 20.1 per 100,000, 16.2 per 100,000 for CMT-1
- Werdelin L. Keiding N., "Hereditary ataxias: epidemiological aspects", Neuroepidemiology. 9(6):321-31, 1990.
Denmark: 6.06 per 100,000 in the 10 to 50-year-old population for combined Hereditary ataxias, hereditary spastic paraplegia and Charcot-Marie-Tooth syndrome
- Radhakrishnan K. el-Mangoush MA. Gerryo SE., "Descriptive epidemiology of selected neuromuscular disorders in Benghazi, Libya.", Acta Neurologica Scandinavica. 75(2):95-100, 1987.
Benghazi Libya: 7.9 per 100,000 for HMSN (6.4 and 1.5 for Types I and II, respectively)
- Combarros O. Calleja J. Polo JM. Berciano J., "Prevalence of hereditary motor and sensory neuropathy in Cantabria.", Acta Neurologica Scandinavica. 75(1):9-12, 1987 Jan.
Cantabria Northern Spain: 28.2 per 100,000 for HMSN
- Aiyesimoju AB. Osuntokun BO. Bademosi O. Adeuja AO., "Hereditary neurodegenerative disorders in Nigerian Africans", Neurology. 34(3):361-2, 1984 Mar.
Nigerian Africans: Of 2.1 million patients seen in 25 years at the University College Hospital, Ibadan, Nigeria, only 3 suffered from 3 Charcot-Marie-Tooth disease
- Skre H., "Genetic and clinical aspects of Charcot-Marie-Tooth's disease", Clinical Genetics 1974: 6: 98-118.
Western Norway: 36 per 100,000 for autosomal dominant CMT, 3.6 per 100,000 for CMT-X and 1.4 per 100,000 for autosomal recessive CMT
- Sorry I don't have the complete reference: Clinical Neurology "The Epidemiology of Neurologic Diseases", Volume 3 Chapter 48.
- Norway: 9-17 per 100,000
- Iceland: 1.6 per 100,000
- North Carolina: 5.4 per 100,000
- Guam: 23 per 100,000
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